Interleukin-1 receptor antagonist (IL-1RA) and interleukin-4 (IL-4) variable number of tandem repeat polymorphisms in schizophrenia and bipolar disorder: an association study in Turkish population

Abstract Background Pro-inflammatory/anti-inflammatory cytokine imbalance in cerebrospinal fluid or plasma of schizophrenia (SCZ) and bipolar disorder (BD) patients has been documented over the last decade. We aim to examine interleukin-1 receptor antagonist (IL-1RA) IL-4 variable number tandem repeat (VNTR) polymorphisms SCZ BD by comparing them with healthy controls. Methods Two hundred thirty-four unrelated (127 SCZ, 107 BD) 204 controls were included. The Structured Clinical Interview for DSM-IV Axis I Disorders was used confirm diagnosis. In addition, polymerase chain reaction technique investigate IL-1RA VNTR polymorphisms. Results Our results showed that distributions genotype allele frequencies not significantly different from control group. 2 homozygous non-significantly higher among than Conclusions study indicates are considered risk factors developing Turkish patients.